Palladium-Catalyzed Addition/Cyclization of (2-Hydroxyaryl)boronic Acids with Alkynylphosphonates: Access to Phosphacoumarins

Dumei Ma; Shanshan Hu; Sirui Chen; Jiaoting Pan; Song Tu; Yingwu Yin; Yuxing Gao; Yufen Zhao

doi:10.1021/acs.orglett.0c03151

Palladium-Catalyzed Addition/Cyclization of (2-Hydroxyaryl)boronic Acids with Alkynylphosphonates: Access to Phosphacoumarins

Org Lett. 2020 Oct 16;22(20):8156-8160. doi: 10.1021/acs.orglett.0c03151. Epub 2020 Sep 30.

Authors

Dumei Ma¹, Shanshan Hu², Sirui Chen¹, Jiaoting Pan², Song Tu¹, Yingwu Yin¹, Yuxing Gao², Yufen Zhao²

Affiliations

¹ Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China.
² Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China.

PMID: 32996770
DOI: 10.1021/acs.orglett.0c03151

Abstract

A facile palladium-catalyzed addition/cyclization of (2-hydroxyaryl)boronic acids with alkynylphosphonates has been developed, providing an effective strategy to construct a series of valuable phosphacoumarins. This methodology features excellent regioselectivity and broad substrate tolerance.

Publication types

Research Support, Non-U.S. Gov't