Cryogel biocomposite containing chitosan-gelatin/cerium-zinc doped hydroxyapatite for bone tissue engineering

Shiqing Wu; Shengzhong Ma; Cheng Zhang; Guangqing Cao; Dongjin Wu; Chunzheng Gao; Sivalingam Lakshmanan

doi:10.1016/j.sjbs.2020.05.045

Cryogel biocomposite containing chitosan-gelatin/cerium-zinc doped hydroxyapatite for bone tissue engineering

Saudi J Biol Sci. 2020 Oct;27(10):2638-2644. doi: 10.1016/j.sjbs.2020.05.045. Epub 2020 Jun 1.

Authors

Shiqing Wu¹, Shengzhong Ma¹, Cheng Zhang¹, Guangqing Cao¹, Dongjin Wu¹, Chunzheng Gao¹, Sivalingam Lakshmanan²

Affiliations

¹ Department of Spinal Surgery, The Second Hospital of Shandong University, No.247 Beiyuan Road, Tianqiao District, Jinan City, Shandong Province 250033, China.
² Department of Chemistry, BIHER, Bharath University, Chennai 600 073, India.

Abstract

The present examination includes manufacture and portrayal of cryogel bio-composite implants containing chitosan-gelatin (CS-GT), cerium-zinc doped hydroxyapatite (CS-GT/Ce-Zn-HA) by cryogelation technique. The prepared cryogel biocomposites (CS-GT/HA and CS-GT/Ce-Zn-HA) were described by scanning electron microscope (SEM) and X-Ray diffraction (XRD) contemplates. The expansion of Ce-Zn in the CS-GT implants essentially expanded growing, diminished swelling, expanded protein sorption, and expanded bactericidal movement. The CS-GT/Ce-Zn-HA biocomposite had non-toxic towards rodent osteoblast cells. So the created CS-GT/Ce-Zn-HA biocomposite has favorable and potential applications over the CS-GT/HA platforms for bone tissue engineering.

Keywords: Antibacterial activity; Biocomposite; Bone; Chitosan; Cryogel; Hydroxyapatite.