Molecular docking analysis of capsaicin with apoptotic proteins

Anitha Roy; Arun Rasheed; Aneymol Varikalam Sleeba; Ponnulakshmi Rajagopal

doi:10.6026/97320630016555

Molecular docking analysis of capsaicin with apoptotic proteins

Bioinformation. 2020 Jul 31;16(7):555-560. doi: 10.6026/97320630016555. eCollection 2020.

Authors

Anitha Roy¹, Arun Rasheed², Aneymol Varikalam Sleeba³, Ponnulakshmi Rajagopal⁴

Affiliations

¹ Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
² Department of Pharmaceutical Chemistry, Alshifa College of Pharmacy, Malappuram, Kerala.
³ Department of Microbiology, St. Xavier's College for Women, Aluva, Kerala-683101, India.
⁴ Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India.

Abstract

Oral cancer is linked with apoptotic proteins such as Bcl-xl, Bcl-2 and Mcl-1. Therefore it is of interest to document the molecular docking analysis of capsaicin (principle present in the Capsicum annum) with apoptotic proteins in this context. We report the molecular binding features of capsaicin with apoptotic proteins such as Bcl-xl, Bcl-2 and Mcl-1 for further consideration.

Keywords: ADME; Capsicum annum; molecular docking; oral cancer.