Mechanisms of Arrhythmias in the Brugada Syndrome

Michiel Blok; Bastiaan J Boukens

doi:10.3390/ijms21197051

Mechanisms of Arrhythmias in the Brugada Syndrome

Int J Mol Sci. 2020 Sep 25;21(19):7051. doi: 10.3390/ijms21197051.

Authors

Michiel Blok^{1

2}, Bastiaan J Boukens^{1

2}

Affiliations

¹ Department of Medical Biology, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
² Department of Experimental Cardiology, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Abstract

Arrhythmias in Brugada syndrome patients originate in the right ventricular outflow tract (RVOT). Over the past few decades, the characterization of the unique anatomy and electrophysiology of the RVOT has revealed the arrhythmogenic nature of this region. However, the mechanisms that drive arrhythmias in Brugada syndrome patients remain debated as well as the exact site of their occurrence in the RVOT. Identifying the site of origin and mechanism of Brugada syndrome would greatly benefit the development of mechanism-driven treatment strategies.

Keywords: Brugada syndrome; RVOT; arrhythmia; fibrosis.

Publication types

Review

MeSH terms

Aged
Animals
Brugada Syndrome* / genetics
Brugada Syndrome* / pathology
Brugada Syndrome* / physiopathology
Electrophysiological Phenomena
Female
Heart Ventricles* / pathology
Heart Ventricles* / physiopathology
Humans
Male
Mice