Reversal of sepsis-induced T cell dysfunction: OX-40 to the rescue?

Edward R Sherwood; David L Williams

doi:10.1002/JLB.3CE0720-468

Reversal of sepsis-induced T cell dysfunction: OX-40 to the rescue?

J Leukoc Biol. 2021 Apr;109(4):689-691. doi: 10.1002/JLB.3CE0720-468. Epub 2020 Sep 29.

Authors

Edward R Sherwood^{1

2}, David L Williams^{2

3}

Affiliations

¹ Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
² Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, Tennessee, USA.
³ Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.

Abstract

The study of Unsinger and colleagues provide important insights into OX40 mediated immunotherapy as a potential approach for the treatment of sepsis induced immune suppression.

Publication types

Editorial
Research Support, N.I.H., Extramural
Comment

MeSH terms

Antibodies
Humans
Immunotherapy
Receptors, OX40*
Sepsis* / therapy
T-Lymphocytes

Substances

Antibodies
Receptors, OX40

Abstract

Publication types

MeSH terms

Substances

Grants and funding