SSAT State-of-the-Art Conference: Advancements in the Microbiome

Miquell O Miller; Purna C Kashyap; Sarah L Becker; Ryan M Thomas; Richard A Hodin; George Miller; Mautin Hundeyin; Smruti Pushalkar; Deirdre Cohen; Deepak Saxena; Benjamin D Shogan; Gareth J Morris-Stiff

doi:10.1007/s11605-020-04551-4

SSAT State-of-the-Art Conference: Advancements in the Microbiome

J Gastrointest Surg. 2021 Jul;25(7):1885-1895. doi: 10.1007/s11605-020-04551-4.

Authors

Affiliations

¹ Department of General Surgery, Stanford University, 300 Pasteur Dr, Stanford, CA, 94305, USA. miquellm@stanford.edu.
² Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA.
³ Departments of Surgery, Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, 32610, USA.
⁴ Department of Surgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
⁵ Departments of Surgery and Cell Biology, New York University School of Medicine, New York, NY, 10016, USA.
⁶ Department of Medicine, New York University School of Medicine, New York, NY, 10016, USA.
⁷ Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, 10010, USA.
⁸ Department of Surgery, University of Chicago, Chicago, IL, 60637, USA.
⁹ Department of General Surgery, Cleveland Clinic, Cleveland, OH, 44195, USA.

PMID: 32989690
DOI: 10.1007/s11605-020-04551-4

Abstract

The microbiome plays a major role in human physiology by influencing obesity, inducing inflammation, and impacting cancer therapies. During the 60th Annual Meeting of the Society of the Alimentary Tract (SSAT) at the State-of-the-Art Conference, experts in the field discussed the influence of the microbiome. This paper is a summary of the influence of the microbiome on obesity, inflammatory bowel disease, pancreatic cancer, cancer therapies, and gastrointestinal optimization. This review shows how the microbiome plays an important role in the development of diseases and surgical complications. Future studies are needed in targeting the gut microbiome to develop individualized therapies.

Keywords: Gastrointestinal optimization; Inflammatory bowel disease; Microbiome; Obesity; Pancreatic cancer.

Publication types

Review

MeSH terms

Gastrointestinal Microbiome*
Humans
Inflammatory Bowel Diseases* / therapy
Microbiota*
Obesity