DNA Methylation Profiling of Premalignant Lesions as a Path to Ovarian Cancer Early Detection

Clin Cancer Res. 2020 Dec 1;26(23):6083-6085. doi: 10.1158/1078-0432.CCR-20-3331. Epub 2020 Sep 28.

Abstract

Genome-wide DNA methylation profiles of serous tubal intraepithelial carcinomas (STIC) resemble methylation profiles of high-grade serous ovarian carcinomas (HGSOC) more closely than normal fallopian tube epithelium. While STICs and HGSOCs share subsets of common hypermethylated regions, DNA methylation can distinguish STICs from HGSOCs to provide proof-of-principle that DNA methylation can identify HGSOC initiation.See related article by Pisanic et al., p. 6310.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Carcinoma, Ovarian Epithelial / diagnosis
  • Carcinoma, Ovarian Epithelial / genetics
  • Cystadenocarcinoma, Serous* / diagnosis
  • Cystadenocarcinoma, Serous* / genetics
  • DNA Methylation
  • Early Detection of Cancer
  • Fallopian Tube Neoplasms*
  • Female
  • Humans
  • Ovarian Neoplasms* / diagnosis
  • Ovarian Neoplasms* / genetics