Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity

Antimicrob Agents Chemother. 2020 Nov 17;64(12):e01920-20. doi: 10.1128/AAC.01920-20. Print 2020 Nov 17.
No abstract available

Keywords: GS-441524; drug metabolism; prodrug; remdesivir; renal clearance.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adenosine / analogs & derivatives
  • Adenosine Monophosphate / analogs & derivatives
  • Alanine / analogs & derivatives
  • COVID-19*
  • Furans
  • Humans
  • Lung
  • Pandemics
  • Pyrroles
  • Renal Dialysis
  • SARS-CoV-2
  • Transplant Recipients
  • Triazines
  • beta-Cyclodextrins

Substances

  • Furans
  • Pyrroles
  • Triazines
  • beta-Cyclodextrins
  • GS-441524
  • SBE4-beta-cyclodextrin
  • remdesivir
  • Adenosine Monophosphate
  • Adenosine
  • Alanine