Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders

PLoS One. 2020 Sep 28;15(9):e0239530. doi: 10.1371/journal.pone.0239530. eCollection 2020.

Abstract

This study assessed the interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and the interactions of gene and physical activity on handgrip strength, arm muscle mass-adjusted handgrip (armGrip), gait speed (GS), timed up and go (TUG), and leg press strength (LPS). Nine single nucleotide polymorphisms (SNPs) containing three IGF-1 SNPs (rs6214, rs5742692, and rs35767), two AKT2 SNPs (rs892119 and rs35817154), two FOXO1 SNPs (rs17446593 and rs10507486), and two FOXO3 SNPs (rs9480865 and rs2153960) were genotyped in 472 unrelated elders with a mean age of 73.8 years. We observed significant interactions of IGF-1 SNP rs6214 and rs35767 with regular physical activity on TUG and GS; and AKT2 SNP rs892119 and FOXO3 SNP rs9480865 with regular physical activity on armGrip. Genotype GG of IGF-1 rs6214 and rs35767 in individuals without regular physical activity had poor performance in TUG and GS, as well as GG of AKT2 rs892119 decreased armGrip in individuals without regular physical activity. After FDR adjustment, no significant gene-gene interactions were found. A sedentary lifestyle may increase the risk of impairing physical performance and regular physical activity is a remedy for sarcopenia, even a little regular physical activity can overcome carrying some risk alleles in this pathway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alleles
  • Exercise / physiology*
  • Female
  • Forkhead Box Protein O1 / genetics*
  • Forkhead Box Protein O3 / genetics*
  • Gene Frequency / genetics
  • Genotype
  • Hand Strength / physiology
  • Humans
  • Insulin-Like Growth Factor I / genetics*
  • Male
  • Physical Functional Performance
  • Polymorphism, Single Nucleotide / genetics*
  • Proto-Oncogene Proteins c-akt / genetics*
  • Sarcopenia / genetics
  • Sedentary Behavior

Substances

  • FOXO1 protein, human
  • FOXO3 protein, human
  • Forkhead Box Protein O1
  • Forkhead Box Protein O3
  • IGF1 protein, human
  • Insulin-Like Growth Factor I
  • AKT2 protein, human
  • Proto-Oncogene Proteins c-akt

Grants and funding

This study was supported by grants from the National Health Research Institutes of Taiwan (NHRI-EX98-9838PI), the Ministry of Science and Technology of Taiwan (MOST 104- 2314-B-039-016, MOST 105-2314-B-039-021-MY3, MOST 105-2314-B-039-025-MY3, MOST 107-2314-B-039-049, MOST 108-2314-B-039-039, MOST 108-2314-B-039-035-MY3 and MOST 108-2314-B-039-031-MY2) and China Medical University Hospital (DMR-109-243). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.