Pediatric patients with orofacial granulomatosis likely to subsequently develop intestinal Crohn's disease: Brief Report

Kristen L Chen; Daren A Diiorio; Yvonne E Chiu; Olayemi Sokumbi

doi:10.1111/pde.14390

Pediatric patients with orofacial granulomatosis likely to subsequently develop intestinal Crohn's disease: Brief Report

Pediatr Dermatol. 2020 Nov;37(6):1162-1164. doi: 10.1111/pde.14390. Epub 2020 Sep 28.

Authors

Kristen L Chen¹, Daren A Diiorio², Yvonne E Chiu³, Olayemi Sokumbi²

Affiliations

¹ School of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
² Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
³ Departments of Dermatology (Section of Pediatric Dermatology) and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

PMID: 32985729
DOI: 10.1111/pde.14390

Abstract

Orofacial granulomatosis (OFG) is an uncommon chronic granulomatous condition presenting as perioral inflammation in the absence of systemic disease. There is continued debate regarding whether OFG is a distinct clinical disorder or a manifestation of orofacial Crohn's disease. Our retrospective review identified 7 patients diagnosed with OFG between 2000 and 2018 at a tertiary pediatric hospital. Four of the 7 patients subsequently developed Crohn's disease with a median delay of 3.1 years (range 0.4-6.9 years). This indicates that gastroenterology evaluation with long-term monitoring for intestinal Crohn's disease is warranted.

Keywords: Crohn's disease; orofacial granulomatosis; pediatrics.

MeSH terms

Child
Crohn Disease* / complications
Crohn Disease* / diagnosis
Granulomatosis, Orofacial* / diagnosis
Granulomatosis, Orofacial* / drug therapy
Granulomatosis, Orofacial* / etiology
Humans
Inflammation
Retrospective Studies
Tertiary Care Centers