Abstract
The protease inhibitor leupeptin prevented multiple step replication of an influenza virus (A/swine/1976/31, H1N1) mediated by staphylococcal proteases. It also suppressed virus replication and development of fatal pneumonia in mice co-infected with the virus and Staphylococcus aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Endopeptidases / metabolism
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Hemagglutinin Glycoproteins, Influenza Virus
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Hemagglutinins, Viral / metabolism*
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Influenza A virus / physiology*
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Leupeptins / pharmacology*
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Metalloendopeptidases*
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Mice
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Oligopeptides / pharmacology*
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Orthomyxoviridae Infections / complications*
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Pneumonia, Staphylococcal / etiology
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Pneumonia, Staphylococcal / prevention & control*
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Protease Inhibitors*
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Protein Processing, Post-Translational / drug effects
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Staphylococcus aureus / enzymology
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Virus Replication / drug effects
Substances
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Hemagglutinin Glycoproteins, Influenza Virus
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Hemagglutinins, Viral
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Leupeptins
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Oligopeptides
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Protease Inhibitors
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Endopeptidases
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Metalloendopeptidases
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auR protein, Staphylococcus aureus
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leupeptin