Inhibitory effect of a protease inhibitor, leupeptin, on the development of influenza pneumonia, mediated by concomitant bacteria

J Gen Virol. 1987 Jul:68 ( Pt 7):2039-41. doi: 10.1099/0022-1317-68-7-2039.

Abstract

The protease inhibitor leupeptin prevented multiple step replication of an influenza virus (A/swine/1976/31, H1N1) mediated by staphylococcal proteases. It also suppressed virus replication and development of fatal pneumonia in mice co-infected with the virus and Staphylococcus aureus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Endopeptidases / metabolism
  • Hemagglutinin Glycoproteins, Influenza Virus
  • Hemagglutinins, Viral / metabolism*
  • Influenza A virus / physiology*
  • Leupeptins / pharmacology*
  • Metalloendopeptidases*
  • Mice
  • Oligopeptides / pharmacology*
  • Orthomyxoviridae Infections / complications*
  • Pneumonia, Staphylococcal / etiology
  • Pneumonia, Staphylococcal / prevention & control*
  • Protease Inhibitors*
  • Protein Processing, Post-Translational / drug effects
  • Staphylococcus aureus / enzymology
  • Virus Replication / drug effects

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus
  • Hemagglutinins, Viral
  • Leupeptins
  • Oligopeptides
  • Protease Inhibitors
  • Endopeptidases
  • Metalloendopeptidases
  • auR protein, Staphylococcus aureus
  • leupeptin