Improving hematopoietic engraftment: Potential role of mesenchymal stromal cell-derived extracellular vesicles

Abstract

The therapeutic effects of mesenchymal stromal cells (MSCs) in graft failure or poor graft function after allogenic hematopoietic stem cell transplantation (HSCT) are currently undergoing clinical evaluation. MSCs exert their functions, at least partially, through the secretion of extracellular vesicles (MSC-EVs). The available information on the biological potential of MSC-EVs to improve hematopoietic function, both in in vitro studies and in reported preclinical models, focusing on the possible mechanisms of these effects are summarized in the current review. The potential advantages of EVs over MSCs are also discussed, as well as the limitations and uncertainties in terms of isolation, characterization, mechanism of action in this setting, and industrial scalability that should be addressed for their potential clinical application.

Keywords: engraftment; exosomes; extracellular vesicles; graft failure; hematopoietic stem cell transplantation; hematopoietic stem cells; mesenchymal stromal cells; microvesicles; poor graft function.