Minimally Invasive Platforms in Biosensing

Prem C Pandey; Govind Pandey; Roger J Narayan

doi:10.3389/fbioe.2020.00894

Minimally Invasive Platforms in Biosensing

Front Bioeng Biotechnol. 2020 Aug 31:8:894. doi: 10.3389/fbioe.2020.00894. eCollection 2020.

Authors

Prem C Pandey¹, Govind Pandey², Roger J Narayan³

Affiliations

¹ Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, India.
² Department of Pediatrics, King George Medical University, Lucknow, India.
³ Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, United States.

Abstract

The interaction of sensing components with body fluids is a basic requirement for clinical diagnostics; a variety of novel platforms have recently been developed for invasive and non-invasive sensing. In this manuscript, recent advancements related to minimally invasive platform for biosensing are reviewed. Many approaches have been utilized for generating minimally invasive platforms that require a small volume of body fluid; for example, the use of small-scale needles known as microneedles for minimally invasive detection has been demonstrated. The use of capillary action in microneedle-assisted biosensing may facilitate the detection of analytes in body fluids. This review considers recent innovations in the structure and performance of minimally invasive sensos.

Keywords: fluorescent biosensors; luminescent sensors; microfabrication; microfluidics; microneedle; transdermal biosensing.

Publication types

Review