Hypertriglyceridemia-Causes, Significance, and Approaches to Therapy

Leinys S Santos-Baez; Henry N Ginsberg

doi:10.3389/fendo.2020.00616

Hypertriglyceridemia-Causes, Significance, and Approaches to Therapy

Front Endocrinol (Lausanne). 2020 Sep 2:11:616. doi: 10.3389/fendo.2020.00616. eCollection 2020.

Authors

Leinys S Santos-Baez¹, Henry N Ginsberg¹

Affiliation

¹ Department of Medicine, Division of Preventive Medicine and Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.

Abstract

Hypertriglyceridemia (HTG) is a common metabolic disorder with both genetic and lifestyle factors playing significant roles in its pathophysiology. HTG poses a risk for the development of cardiovascular disease (CVD) in the population at large and for pancreatitis in about two percent of individuals with extremely high levels of triglycerides (TG). This manuscript summarizes the mechanisms underlying the development of HTG as well as its management, including emerging therapies targeted at specific molecular pathways.

Keywords: apolipoproteinB; chylomicrons; hypertriglyceridemia; lipids; lipoproteins; novel therapeutics; triglycerides; very low density lipoproteins.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Disease Management
Genetic Predisposition to Disease*
Humans
Hypertriglyceridemia / blood
Hypertriglyceridemia / drug therapy*
Hypertriglyceridemia / etiology*
Triglycerides / blood*

Substances

Triglycerides

Abstract

Publication types

MeSH terms

Substances

Grants and funding