Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP)

Piotr Alster; Natalia Madetko; Dariusz Koziorowski; Andrzej Friedman

doi:10.3389/fnins.2020.00893

Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP)

Front Neurosci. 2020 Sep 2:14:893. doi: 10.3389/fnins.2020.00893. eCollection 2020.

Authors

Piotr Alster¹, Natalia Madetko², Dariusz Koziorowski¹, Andrzej Friedman¹

Affiliations

¹ Department of Neurology, Medical University of Warsaw, Warsaw, Poland.
² Department and Clinic of Neurology, Wrocław Medical University, Wrocław, Poland.

Abstract

Progressive supranuclear palsy (PSP) is a neurodegenerative disease based on four-repeat tauopathy pathology. Currently, this entity is not fully recognized in the context of pathogenesis or clinical examination. This review evaluates the association between neuroinflammation and microglial activation with the induction of pathological cascades that result in tauopathy pathology and the clinical manifestation of PSP. Multidimensional analysis was performed by evaluating genetic, biochemical, and neuroimaging biomarkers to determine whether neurodegeneration as an effect of neuroinflammation or neuroinflammation is a consequence of neurodegeneration in PSP. To the best of our knowledge, this review is the first to investigate PSP in this context.

Keywords: PSP; microglia; neurodegeneration; neuroinflammation; progressive supranucelar palsy.

Publication types

Review