Low Concentrations of Dehydroepiandrosterone Sulfate are Associated with Depression and Fatigue in Patients with Non-Small-Cell Lung Cancer After Chemotherapy

Yu-Hung Fang; Meng-Jer Hsieh; Ming-Szu Hung; Yu-Ching Lin; Liang-Tseng Kuo; Mong-Liang Lu; Bor-Show Tzang; Vincent Chin-Hung Chen

doi:10.2147/NDT.S265182

Low Concentrations of Dehydroepiandrosterone Sulfate are Associated with Depression and Fatigue in Patients with Non-Small-Cell Lung Cancer After Chemotherapy

Neuropsychiatr Dis Treat. 2020 Sep 17:16:2103-2109. doi: 10.2147/NDT.S265182. eCollection 2020.

Authors

Yu-Hung Fang¹, Meng-Jer Hsieh^{2

3}, Ming-Szu Hung^{1

4

5}, Yu-Ching Lin^{1

3

4

5}, Liang-Tseng Kuo^{5

6}, Mong-Liang Lu⁷, Bor-Show Tzang^{8

9

10}, Vincent Chin-Hung Chen^{5

11}

Affiliations

¹ Division of Thoracic Oncology, Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.
² Department of Respiratory Therapy, College of Medicine, Chang Gung University, Chiayi, Taiwan.
³ Division of Pulmonary Infection and Critical Care Medicine, Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.
⁴ Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan.
⁵ Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁶ Division of Sports Medicine, Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
⁷ Department of Psychiatry, Wan Fang Hospital, and School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁸ Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.
⁹ Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan.
¹⁰ Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
¹¹ Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan.

Abstract

Background: Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) concentrations were reported to decrease in patients with advanced cancer. However, the clinical significance of DHEA and DHEAS concentrations in patients with NSCLC receiving chemotherapy (CT) has not been sufficiently documented.

Objective: To evaluate the correlation between mental health and hormone concentrations on patients with advanced non-small-cell lung cancer (NSCLC).

Materials and methods: The present study was a cross-sectional analysis based on a self-reported psychological investigation. Salivary samples were collected from 22 patients with advanced NSCLC after CT and 17 healthy controls. The concentrations of DHEA, DHEAS, and cortisol were analyzed to investigate their associations with the results of self-reported questionnaires on psychological health.

Results: Patients with advanced NSCLC exhibited significantly higher Patient Health Questionnaire (PHQ-9) and Startle, Physiological arousal, Anger, and Numbness-Chinese version (SPAN-C) scores, poorer health conditions, lower sleep quality, and more severe fatigue after CT than did healthy controls, and salivary concentrations of DHEA and DHEAS were significantly lower among patients after CT than among controls. DHEAS concentrations were negatively associated with depression scores (PHQ-9, r = -0.496, P = 0.019) and fatigue scores (Brief Fatigue Inventory-Taiwan, r = -0.562, P = 0.006).

Conclusion: Patients with advanced NSCLC after CT had lower DHEA and DHEAS concentrations than did controls. Lower DHEAS concentrations were associated with higher fatigue and depression scores.

Keywords: DHEA; DHEAS; cancer-related fatigue; chemotherapy; lung cancer.