Timing of exposure to environmental adjuvants is critical to mitigate peanut allergy

Johanna M Smeekens; Robert M Immormino; Michael D Kulis; Timothy P Moran

doi:10.1016/j.jaci.2020.09.011

Timing of exposure to environmental adjuvants is critical to mitigate peanut allergy

J Allergy Clin Immunol. 2021 Jan;147(1):387-390.e4. doi: 10.1016/j.jaci.2020.09.011. Epub 2020 Sep 24.

Authors

Johanna M Smeekens¹, Robert M Immormino², Michael D Kulis³, Timothy P Moran²

Affiliations

¹ Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC; University of North Carolina Food Allergy Initiative, Chapel Hill, NC. Electronic address: Smeeken3@email.unc.edu.
² Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC; Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC.
³ Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC; University of North Carolina Food Allergy Initiative, Chapel Hill, NC.

Abstract

Toll-like receptor ligands in indoor dust act as environmental adjuvants to promote sensitization to inhaled peanut in mice. The timing of exposure to environmental adjuvants relative to peanut is a determinant of peanut allergy development.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic*
Allergens / immunology*
Environmental Exposure*
Humans
Peanut Hypersensitivity / immunology*

Substances

Adjuvants, Immunologic
Allergens

Abstract

Publication types

MeSH terms

Substances

Grants and funding