Mitochondrial DNA Haplotypes as Genetic Modifiers of Cancer

Alpaslan Tasdogan; David G McFadden; Prashant Mishra

doi:10.1016/j.trecan.2020.08.004

Mitochondrial DNA Haplotypes as Genetic Modifiers of Cancer

Trends Cancer. 2020 Dec;6(12):1044-1058. doi: 10.1016/j.trecan.2020.08.004. Epub 2020 Sep 23.

Authors

Alpaslan Tasdogan¹, David G McFadden², Prashant Mishra³

Affiliations

¹ Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Department of Internal Medicine, Department of Biochemistry, Simmons Comprehensive Cancer Center, Division of Endocrinology, Program in Molecular Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
³ Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics, Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address: prashant.mishra@utsouthwestern.edu.

PMID: 32980320
DOI: 10.1016/j.trecan.2020.08.004

Abstract

Mitochondria play an essential role in cellular metabolism, generation of reactive oxygen species (ROS), and the initiation of apoptosis. These properties enable mitochondria to be crucial integrators in the pathways of tumorigenesis. An open question is to what extent variation in the mitochondrial genome (mtDNA) contributes to the biological heterogeneity observed in human tumors. In this review, we summarize our current understanding of the role of mtDNA genetics in relation to human cancers.

Keywords: cancer; haplotypes; mitochondria; mtDNA; oncocytoma.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Apoptosis / genetics
Carcinogenesis / genetics*
DNA, Mitochondrial / genetics*
Genes, Modifier*
Genetic Heterogeneity
Genome, Mitochondrial*
Haplotypes
Humans
Loss of Function Mutation
Neoplasms / genetics*
Neoplasms / pathology
Reactive Oxygen Species / metabolism

Substances

DNA, Mitochondrial
Reactive Oxygen Species