Calibration of sodium iodide detectors and reentrant ionization chambers for 212Pb activity in different geometries by HPGe activity determined samples

Elisa Napoli; Vilde Y Stenberg; Asta Juzeniene; Gro E Hjellum; Øyvind S Bruland; Roy H Larsen

doi:10.1016/j.apradiso.2020.109362

Calibration of sodium iodide detectors and reentrant ionization chambers for ²¹²Pb activity in different geometries by HPGe activity determined samples

Appl Radiat Isot. 2020 Dec:166:109362. doi: 10.1016/j.apradiso.2020.109362. Epub 2020 Aug 7.

Authors

Elisa Napoli¹, Vilde Y Stenberg², Asta Juzeniene³, Gro E Hjellum⁴, Øyvind S Bruland⁵, Roy H Larsen⁶

Affiliations

¹ Oncoinvent AS, Oslo, Norway; Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: napoli@oncoinvent.com.
² Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Nucligen AS, Oslo, Norway.
³ Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
⁴ Oncoinvent AS, Oslo, Norway.
⁵ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Oncology, Oslo University Hospital, Oslo, Norway.
⁶ Nucligen AS, Oslo, Norway.

PMID: 32979756
DOI: 10.1016/j.apradiso.2020.109362

Abstract

Lead-212 is a promising radionuclide for cancer therapy, but no primary ²¹²Pb activity standardization has been published. A need therefore exists for accurate estimation of injected doses of ²¹²Pb activity in equilibrium with progeny, when it comes to preclinical and clinical trials. In this study, ²¹²Pb activity was determined using a high purity germanium (HPGe) detector, which allowed the determination of geometry-specific calibration factors for commercially available reentrant ionization chambers (ICs) and sodium iodide (NaI) detectors.

Keywords: Activity calibration; HPGe; Ionization chamber; Pb-212; Sodium iodide detector.