A patient developed encephalopathy two months after a mild case of COVID-19.
MRI Brain demonstrated extensive white matter lesions juxtacortically and subcortically.
Workup for infectious, paraneoplastic, toxic process was negative.
MBP was elevated, prompting diagnosis of post-infectious ADEM following COVID-19.
COVID-19 patients without hypoxia may have post-infectious leukoencephalopathy.
Keywords: Acute disseminated encephalomyelitis; COVID-19; Leukoencephalopathy.