Delayed SARS-COV-2 leukoencephalopathy without Severe Hypoxia

J Neurol Sci. 2020 Nov 15:418:117146. doi: 10.1016/j.jns.2020.117146. Epub 2020 Sep 18.

Abstract

  1. A patient developed encephalopathy two months after a mild case of COVID-19.

  2. MRI Brain demonstrated extensive white matter lesions juxtacortically and subcortically.

  3. Workup for infectious, paraneoplastic, toxic process was negative.

  4. MBP was elevated, prompting diagnosis of post-infectious ADEM following COVID-19.

  5. COVID-19 patients without hypoxia may have post-infectious leukoencephalopathy.

Keywords: Acute disseminated encephalomyelitis; COVID-19; Leukoencephalopathy.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Blood Pressure / physiology
  • Brain / pathology
  • COVID-19 / epidemiology*
  • Delayed Diagnosis
  • Female
  • Humans
  • Hypoxia / epidemiology*
  • Leukoencephalopathies / diagnostic imaging
  • Leukoencephalopathies / epidemiology*
  • Leukoencephalopathies / pathology
  • Leukoencephalopathies / physiopathology
  • Magnetic Resonance Imaging
  • Neuroimaging
  • New York City / epidemiology
  • Pandemics
  • SARS-CoV-2
  • Time Factors
  • White Matter / pathology