Alterations of fatty acid composition and metabolism in APP/PS1 transgenic mice

Neurosci Lett. 2020 Nov 1:738:135401. doi: 10.1016/j.neulet.2020.135401. Epub 2020 Sep 22.

Abstract

Accumulating evidence suggests that abnormal fatty acid composition is related to the development of Alzheimer's disease (AD). However, there is no consistency in the fatty acid profile and metabolism associated with AD pathogenesis. This study aims to define the characteristics of fatty acid composition and metabolism in AD. Using 6-month-old APP/PS1 transgenic mice with wild-type mice as a control, we examined the serum lipids, brain fatty acid composition, and the expression levels of various genes involved in liver fatty acid β-oxidation. The results of our study demonstrate that APP/PS1 mice present decreased serum free fatty acids, altered brain fatty acid profiles, and minimal change in liver fatty acid β-oxidation. Our results suggest that abnormal fatty acid compositions and contents may play potential roles in AD progression. This study provides further evidence for the metabolic basis of AD pathogenesis.

Keywords: APP/PS1 transgenic mice; Alzheimer’s disease; Fatty acid composition; Fatty acid β-oxidation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / drug effects
  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Protein Precursor / drug effects
  • Amyloid beta-Protein Precursor / genetics
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Brain / drug effects*
  • Brain / metabolism*
  • Disease Models, Animal
  • Disease Progression
  • Fatty Acids / metabolism
  • Fatty Acids / pharmacology*
  • Mice

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Fatty Acids