Identification and characterization of invasive multi-drug-resistant (MDR) Bacteroides genomospecies in Canada

Christopher Graham; Alireza Eshaghi; Alicia Sarabia; Sandra Zittermann; Patrick Stapleton; Julianne V Kus; Samir N Patel

doi:10.1099/acmi.0.000111

Identification and characterization of invasive multi-drug-resistant (MDR) Bacteroides genomospecies in Canada

Access Microbiol. 2020 Feb 26;2(5):acmi000111. doi: 10.1099/acmi.0.000111. eCollection 2020.

Authors

Christopher Graham^{1

2}, Alireza Eshaghi³, Alicia Sarabia¹, Sandra Zittermann³, Patrick Stapleton³, Julianne V Kus^{3

4}, Samir N Patel^{3

4}

Affiliations

¹ Trillium Health Partners, Mississauga ON, Canada.
² Department of Medicine, University of Toronto, Toronto ON, Canada.
³ Public Health Ontario Laboratory, Public Health Ontario, Toronto ON, Canada.
⁴ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON, Canada.

Abstract

We identified and characterized a genome of the multi-drug-resistant Bacteroides genomospecies recovered from an invasive specimen from a hospitalized patient in Canada. The strain was resistant to penicillin, pipercillin-tazobactam, meropenem, clindaymycin and metronidazole. The strain harboured a plasmid containing the nimE gene, which has been shown to be associated with metronidazole resistance. The study highlights the importance of being vigilant in suspecting antimicrobial drug resistance when a patient is not improving on therapy.

Keywords: Bacteroides; anaerobic bacteria; genomospecies; metronidazole; multi-drug resistance.

Publication types

Case Reports