Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology

Anqi Zhou; Hui Yu; Jiayi Liu; Jianan Zheng; Yinan Jia; Bingfeng Wu; Lin Xiang

doi:10.3389/fcell.2020.00780

Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology

Front Cell Dev Biol. 2020 Aug 19:8:780. doi: 10.3389/fcell.2020.00780. eCollection 2020.

Authors

Anqi Zhou¹, Hui Yu^{1

2}, Jiayi Liu¹, Jianan Zheng¹, Yinan Jia¹, Bingfeng Wu¹, Lin Xiang^{1

2}

Affiliations

¹ State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
² Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Abstract

The social demand for dental implantation is growing at a rapid rate, while dentists are faced with the dilemma of implantation failures associated with unfavorable osseointegration. Clinical-friendly osteogenesis, angiogenesis and osteoimmunology around dental implants play a pivotal role in a desirable osseointegration and it's increasingly appreciated that Hippo-YAP signaling pathway is implicated in those biological processes both in vitro and in vivo in a variety of study. In this article we review the multiple effects of Hippo-YAP signaling in osseointegration of dental implants by regulating osteogenesis, angiogenesis and osteoimmunology in peri-implant tissue, as well as highlight prospective future directions of relevant investigation.

Keywords: Hippo-YAP; angiogenesis; bone remodeling; implants; osseointegration; osteogenesis; osteoimmunology.

Publication types

Review