Structures and Functions of the 3' Untranslated Regions of Positive-Sense Single-Stranded RNA Viruses Infecting Humans and Animals

Yuanzhi Liu; Yu Zhang; Mingshu Wang; Anchun Cheng; Qiao Yang; Ying Wu; Renyong Jia; Mafeng Liu; Dekang Zhu; Shun Chen; Shaqiu Zhang; XinXin Zhao; Juan Huang; Sai Mao; Xumin Ou; Qun Gao; Yin Wang; Zhiwen Xu; Zhengli Chen; Ling Zhu; Qihui Luo; Yunya Liu; Yanling Yu; Ling Zhang; Bin Tian; Leichang Pan; Xiaoyue Chen

doi:10.3389/fcimb.2020.00453

Structures and Functions of the 3' Untranslated Regions of Positive-Sense Single-Stranded RNA Viruses Infecting Humans and Animals

Front Cell Infect Microbiol. 2020 Aug 27:10:453. doi: 10.3389/fcimb.2020.00453. eCollection 2020.

Authors

Yuanzhi Liu^{1

2

3}, Yu Zhang^{1

2}, Mingshu Wang^{1

2

3}, Anchun Cheng^{1

2

3}, Qiao Yang^{1

2

3}, Ying Wu^{1

2

3}, Renyong Jia^{1

2

3}, Mafeng Liu^{1

2

3}, Dekang Zhu^{2

3}, Shun Chen^{1

2

3}, Shaqiu Zhang^{1

2

3}, XinXin Zhao^{1

2

3}, Juan Huang^{1

2

3}, Sai Mao^{1

2

3}, Xumin Ou^{1

2

3}, Qun Gao^{1

2

3}, Yin Wang², Zhiwen Xu², Zhengli Chen², Ling Zhu², Qihui Luo², Yunya Liu^{1

2

3}, Yanling Yu^{1

2

3}, Ling Zhang^{1

2

3}, Bin Tian^{1

3}, Leichang Pan^{1

3}, Xiaoyue Chen^{1

2

3}

Affiliations

¹ Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
² Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
³ Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.

Abstract

The 3' untranslated region (3' UTR) of positive-sense single-stranded RNA [ssRNA(+)] viruses is highly structured. Multiple elements in the region interact with other nucleotides and proteins of viral and cellular origin to regulate various aspects of the virus life cycle such as replication, translation, and the host-cell response. This review attempts to summarize the primary and higher order structures identified in the 3'UTR of ssRNA(+) viruses and their functional roles.

Keywords: 3′ UTR; functions; ssRNA(+); structures; viruses.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

3' Untranslated Regions / genetics
Animals
Flavivirus* / genetics
Humans
RNA Viruses* / genetics
RNA, Viral / genetics
Virus Replication

Substances

3' Untranslated Regions
RNA, Viral