Commentary: Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

Sachchida Nand Rai; Vivek K Chaturvedi; Brijesh Kumar Singh; Mohan P Singh

doi:10.3389/fnagi.2020.00219

Commentary: Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

Front Aging Neurosci. 2020 Aug 18:12:219. doi: 10.3389/fnagi.2020.00219. eCollection 2020.

Authors

Sachchida Nand Rai¹, Vivek K Chaturvedi¹, Brijesh Kumar Singh², Mohan P Singh¹

Affiliations

¹ Centre of Biotechnology, University of Allahabad, Prayagraj, India.
² Department of Pathology and Cell Biology, Columbia University Medical Centre, Columbia University, New York, NY, United States.

No abstract available

Keywords: Alzheimer's disease; TREM2 (triggering receptor expressed on myeloid cells); amyloid; axonal dystrophy; knockout; mouse model; tau; transgenic mice.

Publication types

Comment