EEG Changes in Time and Time-Frequency Domain During Movement Preparation and Execution in Stroke Patients

Hai Li; Gan Huang; Qiang Lin; Jiangli Zhao; Qiang Fu; Le Li; Yurong Mao; Xijun Wei; Wanzhang Yang; Bingshui Wang; Zhiguo Zhang; Dongfeng Huang

doi:10.3389/fnins.2020.00827

EEG Changes in Time and Time-Frequency Domain During Movement Preparation and Execution in Stroke Patients

Front Neurosci. 2020 Aug 20:14:827. doi: 10.3389/fnins.2020.00827. eCollection 2020.

Authors

Hai Li^{1

2}, Gan Huang³, Qiang Lin^{2

4}, Jiangli Zhao², Qiang Fu^{3

5}, Le Li², Yurong Mao², Xijun Wei¹, Wanzhang Yang¹, Bingshui Wang¹, Zhiguo Zhang³, Dongfeng Huang^{2

6}

Affiliations

¹ Neurorehabilitation Laboratory, Department of Rehabilitation Medicine, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
² Department of Rehabilitation Medicine, Guangdong Engineering Technology Research Center for Rehabilitation Medicine and Clinical Translation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
³ Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
⁴ Department of Rehabilitation Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
⁵ Ira A. Fulton Schools of Engineering, Arizona State University, Tempe, AZ, United States.
⁶ Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Abstract

This study investigated electroencephalogram (EEG) changes during movement preparation and execution in stroke patients. EEG-based event-related potential (ERP) technology was used to measure brain activity changes. Seventeen stroke patients participated in this study and completed ERP tests that were designed to measure EEG changes during unilateral upper limb movements in preparation and execution stages, with Instruction Response Movement (IRM) and Cued Instruction Response Movement (CIRM) paradigms. EEG data were analyzed using motor potential (MP) in the time domain and the mu-rhythm and beta frequency band response mean value (R-means) in the time-frequency domain. In IRM, the MP amplitude at Cz was higher during hemiplegic arm movement than during unaffected arm movement. MP latency was shorter at Cz and the contralesional motor cortex during hemiplegic arm movement in CIRM compared to IRM. No significant differences were found in R-means among locations, between movement sides in both ERP tests. This study presents the brain activity changes in the time and time-frequency domains in stroke patients during movement preparation and execution and supports the contralesional compensation and adjacent-region compensation mechanism of post-stroke brain reconstruction. These findings may contribute to future rehabilitation research about neuroplasticity and technology development such as the brain-computer interface.

Keywords: electroencephalogram; event-related desynchronization; movement execution; movement preparation; movement-related cortical potential; stroke.