Proteomic Analysis Reveals Upregulation of ACE2 (Angiotensin-Converting Enzyme 2), the Putative SARS-CoV-2 Receptor in Pressure-but Not Volume-Overloaded Human Hearts

Johannes Stegbauer; Milena Kraus; Sarah Nordmeyer; Marieluise Kirchner; Matthias Ziehm; Henrik Dommisch; Sebastian Kelle; Marcus Kelm; Istvan Baczko; Ulf Landmesser; Carsten Tschöpe; Christoph Knosalla; Martin Falcke; Matthieu-P Schapranow; Vera Regitz-Zagrosek; Philipp Mertins; Titus Kuehne

doi:10.1161/HYPERTENSIONAHA.120.16261

Proteomic Analysis Reveals Upregulation of ACE2 (Angiotensin-Converting Enzyme 2), the Putative SARS-CoV-2 Receptor in Pressure-but Not Volume-Overloaded Human Hearts

Hypertension. 2020 Dec;76(6):e41-e43. doi: 10.1161/HYPERTENSIONAHA.120.16261. Epub 2020 Sep 24.

Authors

Johannes Stegbauer¹, Milena Kraus², Sarah Nordmeyer^{3

4}, Marieluise Kirchner^{5

6}, Matthias Ziehm^{5

6}, Henrik Dommisch⁷, Sebastian Kelle⁸, Marcus Kelm^{3

9}, Istvan Baczko¹⁰, Ulf Landmesser^{6

11}, Carsten Tschöpe¹¹, Christoph Knosalla^{4

12}, Martin Falcke¹³, Matthieu-P Schapranow², Vera Regitz-Zagrosek^{4

14

15}, Philipp Mertins^{4

5

6}, Titus Kuehne^{3

4

9}

Affiliations

¹ From the Department of Nephrology, Heinrich Heine University Düsseldorf, University Hospital Düsseldorf, Germany (J.S.).
² Digital Health Center, Hasso Plattner Institute, University of Potsdam, Germany (M. Kraus, M.-P.S.).
³ Charité - Universitätsmedizin Berlin, Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Germany (S.N., M. Kelm, T.K.).
⁴ DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany (S.N., C.K., V.R.-Z., P.M., T.K.).
⁵ Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (M. Kirchner, M.Z., P.M.).
⁶ Berlin Institute of Health, Germany (M. Kirchner, M.Z., U.L., P.M.).
⁷ Department of Periodontology, Oral Medicine and Oral Surgery, Charité, Universitätsmedizin Berlin, Germany (H.D.).
⁸ Department of Cardiology, Deutsches Herzzentrum Berlin, Germany (S.K.).
⁹ Department of Congenital Heart Disease - Pediatric Cardiology, Deutsches Herzzentrum Berlin, Germany (M. Kelm, T.K.).
¹⁰ Department of Pharmacology and Pharmacotherapy, University of Szeged, Hungary (I.B.).
¹¹ Department of Cardiology, Charité - Universitätsmedizin Berlin, Germany (U.L., C.T.).
¹² Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Germany (C.K.).
¹³ Mathematical Cell Physiology, Max Delbrück Center for Molecular Medicine, Berlin, Germany (M.F.).
¹⁴ Charité, University medicine Berlin, Berlin, Germany (V.R.-Z).
¹⁵ Department of Cardiology, University Hospital Zürich, University of Zürich, Switzerland (V.R.-Z.).

PMID: 32969280
DOI: 10.1161/HYPERTENSIONAHA.120.16261

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Review

MeSH terms

Angiotensin-Converting Enzyme 2
Area Under Curve
COVID-19
Cardiovascular Diseases / epidemiology
Cardiovascular Diseases / genetics*
Case-Control Studies
Comorbidity
Coronavirus Infections / diagnosis
Coronavirus Infections / epidemiology*
Female
Germany
Humans
Incidence
Logistic Models
Male
Mitral Valve Insufficiency / epidemiology*
Mitral Valve Insufficiency / genetics
Pandemics
Peptidyl-Dipeptidase A / genetics*
Pneumonia, Viral / diagnosis
Pneumonia, Viral / epidemiology*
Proteomics / methods
RNA, Messenger / analysis
Risk Assessment
Severe Acute Respiratory Syndrome / diagnosis
Severe Acute Respiratory Syndrome / epidemiology
Severe Acute Respiratory Syndrome / genetics*
Survival Analysis
Transcriptional Activation / genetics*
Up-Regulation / genetics

Substances

RNA, Messenger
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2