Nesprin-2G tension fine-tunes Wnt/β-catenin signaling

J Cell Biol. 2020 Oct 5;219(10):e202009042. doi: 10.1083/jcb.202009042.

Abstract

How LINC complexes mediate nuclear mechanotransduction remains unclear. In this issue, Déjardin, Carollo, et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201908036) show that the LINC complex protein nesprin-2G is a mechanosensor of epithelial-mesenchymal transitions (EMTs), recruiting α-catenin to the nucleus to attenuate Wnt/β-catenin signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell Nucleus / metabolism
  • Epithelial-Mesenchymal Transition
  • Mechanotransduction, Cellular
  • Nuclear Proteins* / metabolism
  • beta Catenin* / genetics
  • beta Catenin* / metabolism

Substances

  • Nuclear Proteins
  • beta Catenin