Adrenoleukodystrophy

Excerpt

Adrenoleukodystrophy (ALD) is a genetic disorder that follows X linked inheritance pattern in most cases (X-ALD). A unique neonatal form classified as one form of Zellweger syndrome has an autosomal recessive inheritance pattern (N-ALD). Although, the earlier report in the 1900s described the clinical presentations suggestive of this disease.; the terminology and pathophysiology were first reported in the 1970s. The brain, spinal cord, adrenal glands, and testes are the most commonly affected organs. Given the multiple organs, involvement multidisciplinary team approach is highly recommended in the management plan.