NHC-Catalyzed Enantioselective [3 + 3] Annulation to Construct 5,6-Dihydropyrimidin-4-ones

Di Meng; Yangxi Xie; Qiupeng Peng; Jian Wang

doi:10.1021/acs.orglett.0c02832

NHC-Catalyzed Enantioselective [3 + 3] Annulation to Construct 5,6-Dihydropyrimidin-4-ones

Org Lett. 2020 Oct 2;22(19):7635-7639. doi: 10.1021/acs.orglett.0c02832. Epub 2020 Sep 23.

Authors

Di Meng^{1

2}, Yangxi Xie³, Qiupeng Peng³, Jian Wang^{1

3}

Affiliations

¹ School of Biotechnology and Health Sciences, Jiangmen International Healthcare Innovation Institute, Wuyi University, Jiangmen 529020, China.
² School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
³ School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.

PMID: 32964708
DOI: 10.1021/acs.orglett.0c02832

Abstract

The unprecedented enantioselective NHC-catalyzed [3 + 3] annulation of α-bromoenals with amidines via a dual C-N bond formation is described. The protocol allows a rapid preparation of 5,6-dihydropyrimidinones in acceptable yields with good enantioselectivities.

Publication types

Research Support, Non-U.S. Gov't