Controlled Release of Pyrimidine Compound Using Polymeric Coated ZIF-8 Metal-Organic Framework as Glucagon-Like Peptide-1 Receptor Agonist Carrier

Shaikha S AlNeyadi; Naheed Amir; Mohammad A Ghattas; Noor Atatreh; Shaikha S Alketbi; Ruba Al Ajeil; Abdu Adem

doi:10.3390/molecules25184313

Controlled Release of Pyrimidine Compound Using Polymeric Coated ZIF-8 Metal-Organic Framework as Glucagon-Like Peptide-1 Receptor Agonist Carrier

Molecules. 2020 Sep 20;25(18):4313. doi: 10.3390/molecules25184313.

Authors

Shaikha S AlNeyadi¹, Naheed Amir², Mohammad A Ghattas³, Noor Atatreh³, Shaikha S Alketbi¹, Ruba Al Ajeil¹, Abdu Adem^{2

4}

Affiliations

¹ Department of Chemistry, College of Science, UAE University, Al-Ain P.O. Box 15551, UAE.
² Department of Pharmacology, College of Health and Science, UAE University, Al-Ain P.O. Box 17666, UAE.
³ College of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 112612, UAE.
⁴ Department of Pharmacology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, UAE.

Abstract

This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8. The prepared pyrimidine GLP-1 agonist used for the treatment of diabetes type II, was trapped inside polymer coated ZIF-8. The encapsulation of the GLP-1 agonist was confirmed by UV-visible and FT-IR spectroscopies. Furthermore, the release kinetics of GLP-1 agonist drug from alginate-coated ZIF-8 were investigated in phosphate-buffered saline at 37 °C at pH 8 and 1.5. The alginate-coated ZIF-8 exhibited much faster drug release at basic pH than at pH 1.5, indicating the potential of the alginate-coated ZIF-8 system to overcome the fast degradation at acidic pH of the stomach and improve the drug's activity. This study may open the way for the synthesis of new metal organic frameworks (MOFs) to enhance drug delivery systems.

Keywords: GLP-1 agonist; ZIF-8; alginate; antidiabetic; pyrimidine.

MeSH terms

Alginates / chemistry*
Alginates / metabolism
Blood Glucose / metabolism
Coated Materials, Biocompatible / chemistry
Delayed-Action Preparations / chemistry*
Diabetes Mellitus, Type 2 / drug therapy
Drug Carriers / chemistry*
Drug Compounding
Drug Liberation
Glucagon-Like Peptide-1 Receptor / agonists*
Humans
Hydrogen-Ion Concentration
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / pharmacology
Imidazoles / chemistry*
Metal-Organic Frameworks / chemistry*
Molecular Docking Simulation
Pyrimidines / chemistry*
Pyrimidines / pharmacology
Zinc / chemistry
Zinc / metabolism

Substances

Alginates
Blood Glucose
Coated Materials, Biocompatible
Delayed-Action Preparations
Drug Carriers
Glucagon-Like Peptide-1 Receptor
Hypoglycemic Agents
Imidazoles
Metal-Organic Frameworks
Pyrimidines
ZIF-8 metal-organic framework
Zinc