Regulation of Apoptosis by the Bcl-2 Family of Proteins: Field on a Brink

Cells. 2020 Sep 18;9(9):2121. doi: 10.3390/cells9092121.

Abstract

Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...].

Keywords: Bcl-2 proteins as therapeutic targets; apoptosis; cancer; mitochondrial outer membrane permeabilization; protein–membrane interactions.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Apoptosis / drug effects*
  • Apoptosis / genetics
  • Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • Mitochondrial Membranes / drug effects
  • Mitochondrial Membranes / metabolism
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors
  • Proto-Oncogene Proteins c-bcl-2 / genetics*
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Signal Transduction
  • Sulfonamides / pharmacology*

Substances

  • Antineoplastic Agents
  • BCL2 protein, human
  • Bridged Bicyclo Compounds, Heterocyclic
  • Proto-Oncogene Proteins c-bcl-2
  • Sulfonamides
  • venetoclax