Abstract
Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...].
Keywords:
Bcl-2 proteins as therapeutic targets; apoptosis; cancer; mitochondrial outer membrane permeabilization; protein–membrane interactions.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects*
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Apoptosis / genetics
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
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Gene Expression Regulation, Neoplastic*
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Humans
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Mitochondria / drug effects
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Mitochondria / metabolism
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Mitochondrial Membranes / drug effects
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Mitochondrial Membranes / metabolism
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Neoplasms / drug therapy*
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Neoplasms / genetics
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Neoplasms / metabolism
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Neoplasms / pathology
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Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors
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Proto-Oncogene Proteins c-bcl-2 / genetics*
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Signal Transduction
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Sulfonamides / pharmacology*
Substances
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Antineoplastic Agents
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BCL2 protein, human
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Bridged Bicyclo Compounds, Heterocyclic
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Proto-Oncogene Proteins c-bcl-2
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Sulfonamides
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venetoclax