The strategies and techniques of drug discovery from natural products

Pharmacol Ther. 2020 Dec:216:107686. doi: 10.1016/j.pharmthera.2020.107686. Epub 2020 Sep 19.

Abstract

Natural products have been the main sources of new drugs. The different strategies have been developed to find the new drugs based on natural products. The traditional and ethic medicines have provided information on the therapeutic effects and resulted in some notable drug discovery of natural products. The special activities of the medicine plants such as the side effects have inspired scientists to develop the novel small molecular. The microorganisms and the endogenous active substances from human or animal also become the important approaches to the drug discovery. The tremendous progress in technology led to the new strategies in drug discovery from natural products. The bioinformation and artificial intelligence have facilitated the research and development of natural products. We will provide a scene of strategies and technologies for drug discovery from natural products in this review.

Keywords: Drug discovery; Natural product; Strategy; Technique.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Artificial Intelligence
  • Bacteria / chemistry*
  • Biological Products / isolation & purification
  • Biological Products / pharmacology*
  • Biological Products / toxicity
  • Drug Discovery*
  • High-Throughput Screening Assays
  • Humans
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Extracts / toxicity
  • Tissue Extracts / chemistry*

Substances

  • Biological Products
  • Plant Extracts
  • Tissue Extracts