Gliomas, germ cell tumors, and craniopharyngioma

Paul Aridgides; Geert O Janssens; Steve Braunstein; Shauna Campbell; Matthew Poppe; Erin Murphy; Shannon MacDonald; Matthew Ladra; Claire Alapetite; Daphne Haas-Kogan

doi:10.1002/pbc.28401

Gliomas, germ cell tumors, and craniopharyngioma

Pediatr Blood Cancer. 2021 May:68 Suppl 2:e28401. doi: 10.1002/pbc.28401. Epub 2020 Sep 22.

Authors

Affiliations

¹ Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY, 13210.
² Department of Radiation Oncology, University Medical Center Utrecht and Princess Máxima Center for Pediatric Oncology, Utrecht, GA, 3508, The Netherlands.
³ Department of Radiation Oncology, University of California, Ron Conway Family Gateway Medical Building, 1825 Fourth St. 1st floor M1215, San Francisco, CA, 94115.
⁴ Department of Radiation Oncology, Cleveland Clinic, 9500 Euclid Avenue / CA-50, Cleveland, OH, 44195.
⁵ Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, 1950 Circle of Hope, Radiation Oncology, 1570, Salt Lake City, UT, 84112.
⁶ Department of Radiation Oncology, Cleveland Clinic, Mail Code CA5, 9500 Euclid Avenue, Cleveland, OH, 44195.
⁷ Francis H Burr Proton Therapy Center, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
⁸ Department of Radiation Oncology, Johns Hopkins Kimmel Cancer Center, 401 N. Broadway, Weinberg Suite 1440, Baltimore, MD, 21231.
⁹ Department of Radiation Oncology, Institut Curie, Paris, France.
¹⁰ Department of Radiation Oncology, Dana-Farber Cancer Institute, D1622, 450 Brookline Ave, Brookline, MA, 02215.

PMID: 32960496
DOI: 10.1002/pbc.28401

Abstract

This report summarizes the current multimodality treatment approaches for children with low- and high-grade gliomas, germinoma, and nongerminomatous germ cell tumors, and craniopharyngiomas used in the Children's Oncology Group (COG) and the International Society of Pediatric Oncology (SIOP). Treatment recommendations are provided in the context of historical approaches regarding the roles of surgery, radiation, and chemotherapy. Future research strategies for these tumors in both COG and SIOP are also discussed.

Keywords: chemotherapy; craniopharyngioma; germ cell tumors; gliomas; protons; radiation therapy; surgery.

Publication types

Review

MeSH terms

Child
Combined Modality Therapy
Craniopharyngioma / pathology
Craniopharyngioma / therapy*
Glioma / pathology
Glioma / therapy*
Humans
Neoplasms, Germ Cell and Embryonal / pathology
Neoplasms, Germ Cell and Embryonal / therapy*
Pituitary Neoplasms / pathology
Pituitary Neoplasms / therapy*
Prognosis