Research progress of 18F labeled small molecule positron emission tomography (PET) imaging agents

Mingliang Zhang; Shufeng Li; Hang Zhang; Haiwei Xu

doi:10.1016/j.ejmech.2020.112629

Research progress of ¹⁸F labeled small molecule positron emission tomography (PET) imaging agents

Eur J Med Chem. 2020 Nov 1:205:112629. doi: 10.1016/j.ejmech.2020.112629. Epub 2020 Jul 25.

Authors

Mingliang Zhang¹, Shufeng Li¹, Hang Zhang², Haiwei Xu³

Affiliations

¹ Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Co-innovation Center of Henan Province for New Drug R&D and Preclinical Safety, and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China.
² Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Co-innovation Center of Henan Province for New Drug R&D and Preclinical Safety, and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China. Electronic address: hangzhang@zzu.edu.cn.
³ Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Co-innovation Center of Henan Province for New Drug R&D and Preclinical Safety, and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China. Electronic address: xhwei01@126.com.

PMID: 32956956
DOI: 10.1016/j.ejmech.2020.112629

Abstract

With the development of positron emission tomography (PET) technology, a variety of PET imaging agents labeled with radionuclide ¹⁸F have been developed and widely used in the diagnosis and treatment of various clinical diseases in recent years. For example, they have showed a great value of study in the field of tumor detection, tumor treatment and evaluation of tumor therapy in a non-invasive, qualitative and quantitative way. In this review, we highlight the recent development in chemical synthesis, structure and characterization, imaging characterization, and potential applications of these ¹⁸F labeled small molecule PET imaging agents for the past five years. The development and application of ¹⁸F labeled small molecules will expand our knowledge of the function and distribution of diseases-related molecular targets and shed light on the diagnosis and treatment of various diseases including tumors.

Keywords: (18)F; Imaging; Labeling approach; PET; Probe.

Publication types

Review

MeSH terms

Animals
Fluorine Radioisotopes / chemistry*
Humans
Isotope Labeling
Positron-Emission Tomography / methods*
Small Molecule Libraries / chemistry*

Substances

Fluorine Radioisotopes
Small Molecule Libraries
Fluorine-18