Comparative genomics of CXCR4MUT and CXCR4WT single cells in Waldenström's macroglobulinemia

Blood Adv. 2020 Sep 22;4(18):4550-4553. doi: 10.1182/bloodadvances.2020001775.

Authors

Cristina Jiménez¹, Lian Xu¹, Nickolas Tsakmaklis¹, Maria G Demos¹, Amanda Kofides¹, Gloria G Chan¹, Maria Luisa Guerrera¹, Jiaji G Chen¹, Xia Liu¹, Manit Munshi¹, Christopher J Patterson¹, Guang Yang^{1

2}, Jorge J Castillo^{1

2}, Steven P Treon^{1

2}, Zachary R Hunter^{1

2}

Affiliations

¹ Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA; and.
² Department of Medicine, Harvard Medical School, Boston, MA.

Abstract

Single-cell whole-genome amplification can be used to interrogate the genomic architecture of Waldenström’s macroglobulinemia.
The mutational signature of CXCR4^MUT cells may be associated with alterations in DNA repairing genes and tumor suppressors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Genomics
Humans
Immunoglobulin M
Waldenstrom Macroglobulinemia* / genetics

Substances

Immunoglobulin M