Seeing the fetus from a DOHaD perspective: discussion paper from the advanced imaging techniques of DOHaD applications workshop held at the 2019 DOHaD World Congress

Janna L Morrison; Oyekoya T Ayonrinde; Alison S Care; Geoffrey D Clarke; Jack R T Darby; Anna L David; Justin M Dean; Stuart B Hooper; Marcus J Kitchen; Christopher K Macgowan; Andrew Melbourne; Erin V McGillick; Charles A McKenzie; Navin Michael; Nuruddin Mohammed; Suresh Anand Sadananthan; Eric Schrauben; Timothy R H Regnault; S Sendhil Velan

doi:10.1017/S2040174420000884

Seeing the fetus from a DOHaD perspective: discussion paper from the advanced imaging techniques of DOHaD applications workshop held at the 2019 DOHaD World Congress

J Dev Orig Health Dis. 2021 Apr;12(2):153-167. doi: 10.1017/S2040174420000884. Epub 2020 Sep 21.

Authors

Janna L Morrison¹, Oyekoya T Ayonrinde^{2

3}, Alison S Care⁴, Geoffrey D Clarke⁵, Jack R T Darby¹, Anna L David⁶, Justin M Dean⁷, Stuart B Hooper^{8

9}, Marcus J Kitchen¹⁰, Christopher K Macgowan¹¹, Andrew Melbourne¹², Erin V McGillick^{8

9}, Charles A McKenzie^{13

14}, Navin Michael¹⁵, Nuruddin Mohammed¹⁶, Suresh Anand Sadananthan¹⁵, Eric Schrauben¹⁷, Timothy R H Regnault^{14

18

19}, S Sendhil Velan^{20

15}

Affiliations

¹ Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
² Fiona Stanley Hospital, Murdoch, WA, Australia.
³ Medical School, The University of Western Australia, Perth, WA, Australia.
⁴ The Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
⁵ Department of Radiology, University of Texas Health Science Center, San Antonio, TX, USA.
⁶ Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
⁷ Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
⁸ The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.
⁹ The Department of Obstetrics and Gynecology, Monash University, Melbourne, Victoria, Australia.
¹⁰ School of Physics and Astronomy, Monash University, Melbourne, Victoria, Australia.
¹¹ Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
¹² School of Biomedical Engineering and Imaging Sciences, Kings College London, London, UK.
¹³ Department of Medical Biophysics, Western University, London, ON, Canada.
¹⁴ Lawson Health Research Institute and Children's Health Research Institute, London, ON, Canada.
¹⁵ Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore.
¹⁶ Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, Aga Khan University Hospital, Karachi, Pakistan.
¹⁷ Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada.
¹⁸ Department of Obstetrics and Gynecology, Western University, London, ON, Canada.
¹⁹ Department of Physiology and Pharmacology, Western University, London, ON, Canada.
²⁰ Singapore Bioimaging Consortium, Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore.

PMID: 32955011
DOI: 10.1017/S2040174420000884

Abstract

Advanced imaging techniques are enhancing research capacity focussed on the developmental origins of adult health and disease (DOHaD) hypothesis, and consequently increasing awareness of future health risks across various subareas of DOHaD research themes. Understanding how these advanced imaging techniques in animal models and human population studies can be both additively and synergistically used alongside traditional techniques in DOHaD-focussed laboratories is therefore of great interest. Global experts in advanced imaging techniques congregated at the advanced imaging workshop at the 2019 DOHaD World Congress in Melbourne, Australia. This review summarizes the presentations of new imaging modalities and novel applications to DOHaD research and discussions had by DOHaD researchers that are currently utilizing advanced imaging techniques including MRI, hyperpolarized MRI, ultrasound, and synchrotron-based techniques to aid their DOHaD research focus.

Keywords: DOHaD; MRI; fetus; synchrotron; ultrasound.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomedical Research / trends*
Diagnostic Imaging / methods*
Female
Fetal Diseases / diagnosis*
Fetal Diseases / diagnostic imaging
Fetus / diagnostic imaging
Fetus / pathology*
Humans
Pregnancy
Societies, Scientific

Abstract

Publication types

MeSH terms

Grants and funding