Three-Component Reactions of Alkynone o-Methyloximes, Element Selenium, and Boronic Acids Leading to 4-Organoselenylisoxazoles

Jian Wu; Ye-Fei Yang; Xiao-Bo Huang; Wen-Xia Gao; Yun-Bing Zhou; Miao-Chang Liu; Hua-Yue Wu

doi:10.1021/acsomega.0c03254

Three-Component Reactions of Alkynone o-Methyloximes, Element Selenium, and Boronic Acids Leading to 4-Organoselenylisoxazoles

ACS Omega. 2020 Aug 28;5(36):23358-23363. doi: 10.1021/acsomega.0c03254. eCollection 2020 Sep 15.

Authors

Jian Wu¹, Ye-Fei Yang¹, Xiao-Bo Huang¹, Wen-Xia Gao¹, Yun-Bing Zhou¹, Miao-Chang Liu¹, Hua-Yue Wu¹

Affiliation

¹ College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, People's Republic of China.

Abstract

We report an Ag-catalyzed one-pot three-component reaction of alkynone o-methyloxime, element selenium, and boronic acid, providing a facile route to selenated isoxazole product. This protocol features high efficiency, wide substrate scope, and the use of selenium powder as the selenium source.