Poly(lactic- co-glycolic acid)-based composite bone-substitute materials

Duoyi Zhao; Tongtong Zhu; Jie Li; Liguo Cui; Zhiyu Zhang; Xiuli Zhuang; Jianxun Ding

doi:10.1016/j.bioactmat.2020.08.016

Poly(lactic- co-glycolic acid)-based composite bone-substitute materials

Bioact Mater. 2020 Aug 29;6(2):346-360. doi: 10.1016/j.bioactmat.2020.08.016. eCollection 2021 Feb.

Authors

Duoyi Zhao^{1

2}, Tongtong Zhu^{1

3}, Jie Li¹, Liguo Cui^{1

4}, Zhiyu Zhang², Xiuli Zhuang^{1

4}, Jianxun Ding^{1

4}

Affiliations

¹ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China.
² Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, 4 Chongshandong Road, Shenyang, 110032, PR China.
³ Department of Orthopedics, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130033, PR China.
⁴ Jilin Biomedical Polymers Engineering Laboratory, 5625 Renmin Street, Changchun, 130022, PR China.

Abstract

Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics. Recently, poly(lactic-co-glycolic acid) (PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility, degradability, mechanical properties, and capabilities to promote bone regeneration. In this article, we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances, elaborate on their applications for bone regeneration with or without bioactive factors, and prospect the challenges and opportunities in clinical bone regeneration.

Keywords: Bone regeneration; Bone tissue engineering; Bone-substitute material; Composite organic−inorganic biomaterial; Poly(lactic-co-glycolic acid).

Publication types

Review