Pd-Catalyzed Enantioselective Hydroalkynylation of Cyclopropenes

Longyang Dian; Ilan Marek

doi:10.1021/acscatal.9b04960

Pd-Catalyzed Enantioselective Hydroalkynylation of Cyclopropenes

ACS Catal. 2020 Jan 17;10(2):1289-1293. doi: 10.1021/acscatal.9b04960. Epub 2019 Dec 26.

Authors

Longyang Dian¹, Ilan Marek¹

Affiliation

¹ Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Technion City, Haifa, 32000, Israel.

Abstract

We report herein an easy, mild, and robust Pd-catalyzed enantioselective hydroalkynylation reaction of achiral cyclopropenes. Commercially available Pd(acac)₂ and (R)-DM-BINAP proved to be the best combination to reach high diastereo- and enantioselectivities.