Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome

Marlijn Hoeks; Tim Bagguley; Corine van Marrewijk; Alex Smith; David Bowen; Dominic Culligan; Seye Kolade; Argiris Symeonidis; Hege Garelius; Michail Spanoudakis; Saskia Langemeijer; Rian Roelofs; Erwin Wiegerinck; Aurelia Tatic; Sally Killick; Panagiotis Panagiotidis; Oana Stanca; Eva Hellström-Lindberg; Jaroslav Cermak; Melanie van der Klauw; Hanneke Wouters; Marian van Kraaij; Nicole Blijlevens; Dorine W Swinkels; Theo de Witte; EUMDS Registry Participants

doi:10.1038/s41375-020-01022-2

Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome

Leukemia. 2021 Jun;35(6):1745-1750. doi: 10.1038/s41375-020-01022-2. Epub 2020 Sep 18.

Authors

Marlijn Hoeks^{1

2

3}, Tim Bagguley⁴, Corine van Marrewijk⁵, Alex Smith⁴, David Bowen⁶, Dominic Culligan⁷, Seye Kolade⁸, Argiris Symeonidis⁹, Hege Garelius¹⁰, Michail Spanoudakis^{11

12}, Saskia Langemeijer⁵, Rian Roelofs¹³, Erwin Wiegerinck¹³, Aurelia Tatic¹⁴, Sally Killick¹⁵, Panagiotis Panagiotidis¹⁶, Oana Stanca¹⁷, Eva Hellström-Lindberg¹⁸, Jaroslav Cermak¹⁹, Melanie van der Klauw²⁰, Hanneke Wouters²⁰, Marian van Kraaij⁵, Nicole Blijlevens⁵, Dorine W Swinkels¹³, Theo de Witte²¹; EUMDS Registry Participants

Collaborators

EUMDS Registry Participants:
R Stauder, A Walder, M Pfeilstöcker, A Schoenmetzler-Makrai, S Burgstaller, J Thaler, I Mandac Rogulj, M Krejci, J Voglova, P Rohon, A Jonasova, J Cermak, D Mikulenkova, I Hochova, P D Jensen, M S Holm, L Kjeldsen, I H Dufva, H Vestergaard, D Re, B Slama, P Fenaux, B Choufi, S Cheze, D Klepping, B Salles, B de Renzis, L Willems, D De Prost, J Gutnecht, S Courby, V Siguret, G Tertian, L Pascal, M Chaury, E Wattel, A Guerci, L Legros, P Fenaux, R Itzykson, L Ades, F Isnard, L Sanhes, R Benramdane, A Stamatoullas, S Amé, O Beyne-Rauzy, E Gyan, U Platzbecker, C Badrakan, U Germing, M Lübbert, R Schlenk, I Kotsianidis, C Tsatalas, V Pappa, A Galanopoulos, E Michali, P Panagiotidis, N Viniou, A Katsigiannis, P Roussou, E Terpos, A Kostourou, Z Kartasis, A Pouli, K Palla, V Briasoulis, E Hatzimichael, G Vassilopoulos, A Symeonidis, A Kourakli, P Zikos, A Anagnostopoulos, M Kotsopoulou, K Megalakaki, M Protopapa, E Vlachaki, P Konstantinidou, G Stemer, A Nemetz, U Gotwin, O Cohen, M Koren, E Levy, U Greenbaum, S Gino-Moor, M Price, Y Ofran, A Winder, N Goldshmidt, S Elias, R Sabag, I Hellman, M Ellis, A Braester, H Rosenbaum, S Berdichevsky, G Itzhaki, O Wolaj, S Yeganeh, O Katz, K Filanovsky, N Dali, M Mittelman, L Malcovati, L Fianchi, A Vd Loosdrecht, V Matthijssen, A Herbers, H Pruijt, N Aboosy, F de Vries, G Velders, E Jacobs, S Langemeijer, M MacKenzie, C Lensen, P Kuijper, K Madry, M Camara, A Almeida, G Vulkan, O Stanca Ciocan, A Tatic, A Savic, C Pedro, B Xicoy, P Leiva, J Munoz, V Betes, C Benavente, M Lozano, M Martinez, P Iniesta, T Bernal, M Diez Campelo, D Tormo, R Andreu Lapiedra, G Sanz, E Hesse Sundin, H Garelius, C Karlsson, P Antunovic, A Jönsson, L Brandefors, L Nilsson, P Kozlowski, E Hellstrom-Lindberg, M Grövdal, K Larsson, J Wallvik, F Lorenz, E Ejerblad, D Culligan, C Craddock, S Kolade, P Cahalin, S Killick, S Ackroyd, C Wong, A Warren, M Drummond, C Hall, K Rothwell, S Green, S Ali, D Bowen, M Karakantza, M Dennis, G Jones, J Parker, A Bowen, R Radia, E Das-Gupta, P Vyas, E Nga, D Creagh, J Ashcroft, J Mills, L Bond

Affiliations

¹ Centre for Clinical Transfusion Research, Sanquin Research, Leiden, The Netherlands. marlijn.hoeks@radboudumc.nl.
² Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. marlijn.hoeks@radboudumc.nl.
³ Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands. marlijn.hoeks@radboudumc.nl.
⁴ Epidemiology and Cancer Statistics Group, University of York, York, UK.
⁵ Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁶ St. James's Institute of Oncology, Leeds Teaching Hospitals, Leeds, UK.
⁷ Department of Hematology, Aberdeen Royal Infirmary, Aberdeen, UK.
⁸ Department of Hematology, Blackpool Victoria Hospital, Blackpool, Lancashire, UK.
⁹ Department of Medicine, Division of Hematology, University of Patras Medical School, Patras, Greece.
¹⁰ Department of Medicine, Sect. of Hematology and Coagulation, Sahlgrenska University Hospital, Göteborg, Sweden.
¹¹ Department of Hematology, Airedale NHS Trust, Airdale, UK.
¹² Department of Haematology, Warrington and Halton Teaching Hospitals NHS foundation Trust, Cheshire, UK.
¹³ Department of Laboratory Medicine, Hepcidinanalysis.com, and Radboudumc Expertise Center for Iron Disorders, Radboud University Medical Center, Nijmegen, The Netherlands.
¹⁴ Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
¹⁵ Department of Hematology, Royal Bournemouth Hospital, Bournemouth, UK.
¹⁶ Department of Haematology, 1st Department of Propedeutic Internal Medicine, National and Kapodistrian University of Athens, Medical School, Laikon General Hospital, Athens, Greece.
¹⁷ Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
¹⁸ Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm, Sweden.
¹⁹ Department of Clinical Hematology, Institute of Hematology and Blood Transfusion, Praha, Czech Republic.
²⁰ Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
²¹ Nijmegen Center for Molecular Life Sciences, Department of Tumor Immunology, Radboud University Medical Center, Nijmegen, The Netherlands.

No abstract available

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Blood Transfusion / mortality*
Female
Follow-Up Studies
Humans
Iron / adverse effects*
Iron Overload / etiology
Iron Overload / metabolism
Iron Overload / mortality*
Iron Overload / pathology
Male
Middle Aged
Myelodysplastic Syndromes / mortality*
Myelodysplastic Syndromes / pathology
Myelodysplastic Syndromes / therapy
Prognosis
Prospective Studies
Survival Rate

Substances

Iron