cAMP Signaling in Nanodomains

Peter K Jackson

doi:10.1016/j.cell.2020.08.041

cAMP Signaling in Nanodomains

Cell. 2020 Sep 17;182(6):1379-1381. doi: 10.1016/j.cell.2020.08.041.

Author

Peter K Jackson¹

Affiliation

¹ Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University, Stanford, CA 94305, USA. Electronic address: pjackson@stanford.edu.

PMID: 32946779
DOI: 10.1016/j.cell.2020.08.041

Abstract

Cyclic-3',5'-adenosine monophosphate (cAMP) is an ancient second messenger but organizing signaling selectivity on the nanoscale is poorly understood. Examining transport of a new fluorescent cAMP probe, Bock and coworkers observe "buffered diffusion" and establish phosphodiesterase activity can organize cAMP nanodomains, while Zhao and coworkers find that protein kinase A regulatory subunits assemble liquid droplets to further localize cAMP signaling.

Publication types

Comment

MeSH terms

Adenosine Monophosphate
Cyclic AMP*
Cyclic AMP-Dependent Protein Kinases* / metabolism
Diffusion
Signal Transduction

Substances

Adenosine Monophosphate
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases

Abstract

Publication types

MeSH terms

Substances

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