Gut Microbes' Impact on Oncogenic Drivers: Location Matters

Michael G White; Jennifer A Wargo

doi:10.1016/j.molcel.2020.08.021

Gut Microbes' Impact on Oncogenic Drivers: Location Matters

Mol Cell. 2020 Sep 17;79(6):878-880. doi: 10.1016/j.molcel.2020.08.021.

Authors

Michael G White¹, Jennifer A Wargo²

Affiliations

¹ Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
² Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: jwargo@mdanderson.org.

Abstract

Recent work by Kadosh et al. (2020) suggests that mutant p53 activity in gut epithelia is influenced by local production of microbial metabolites. The switch of p53 from tumor suppressor to oncogene is location-dependent and is impacted by microbially derived gallic acid.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Carcinogenesis
Gastrointestinal Microbiome*
Humans
Oncogenes
Tumor Suppressor Protein p53 / genetics

Substances

Tumor Suppressor Protein p53

Abstract

Publication types

MeSH terms

Substances

Grants and funding