Limitations of Ribotyping as Genotyping Method for Corynebacterium ulcerans

Emerg Infect Dis. 2020 Oct;26(10):2457-2459. doi: 10.3201/eid2610.200086.

Abstract

We conducted molecular typing of a Corynebacterium ulcerans isolate from a woman who died in Japan in 2016. Genomic DNA modification might have affected the isolate's ribotyping profile. Multilocus sequence typing results (sequence type 337) were more accurate. Whole-genome sequencing had greater ability to discriminate lineages at high resolution.

Keywords: Corynebacterium ulcerans; bacteria; genome sequence; molecular typing; multilocus sequence typing; phylogeny; ribotyping; whole-genome sequencing; zoonoses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Corynebacterium* / genetics
  • Female
  • Genotype
  • Humans
  • Japan / epidemiology
  • Multilocus Sequence Typing
  • Ribotyping

Supplementary concepts

  • Corynebacterium ulcerans