Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum

Mohammed M A Ahmed; Mohamed A Albadry; Ehab A Ragab; Elsayed M El-Ghaly; Said K Ismail; Zulfiqar Ali; Shabana I Khan; Amar G Chittiboyina; Ikhlas A Khan

doi:10.1080/14786419.2020.1821015

Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum

Nat Prod Res. 2022 Apr;36(7):1842-1850. doi: 10.1080/14786419.2020.1821015. Epub 2020 Sep 18.

Authors

Mohammed M A Ahmed^{1

2}, Mohamed A Albadry², Ehab A Ragab¹, Elsayed M El-Ghaly¹, Said K Ismail¹, Zulfiqar Ali², Shabana I Khan^{2

3}, Amar G Chittiboyina², Ikhlas A Khan^{2

3}

Affiliations

¹ Faculty of Pharmacy, Department of Pharmacognosy, Al-Azhar University, Cairo, Egypt.
² National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA.
³ Division of Pharmacognosy, Department of Biomolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS, USA.

PMID: 32945198
DOI: 10.1080/14786419.2020.1821015

Abstract

Four undescribed cembranoids, sarcoroseolides A-D (1-4) along with nine reported related cembranoids (5-13) were isolated from the soft coral Sarcophyton roseum. The chemical structures of sarcoroseolides A-D were elucidated by extensive 1 D and 2 D NMR as well as HR-ESIMS spectroscopic data. Moreover, the geometric and absolute configurations were assigned by the modified Mosher's method and/or NOESY experiments. The extract and the isolated metabolites were evaluated for their potential anti-inflammatory and cytotoxic activities.

Keywords: Sarcophyton roseum; Soft coral; cembranoids; sarcoroseolides A-D.

MeSH terms

Animals
Anthozoa* / chemistry
Diterpenes* / chemistry
Diterpenes* / pharmacology
Indian Ocean
Magnetic Resonance Spectroscopy
Molecular Structure

Substances

Diterpenes