Two new 2-arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cell

Tjitjik Srie Tjahjandarie; Mulyadi Tanjung; Ratih Dewi Saputri; Devina Oktari Rahayu; Alfiah Nur Irza Gunawan; Muhammad Fajar Aldin

doi:10.1080/14786419.2020.1821016

Two new 2-arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cell

Nat Prod Res. 2021 Dec;35(24):5637-5642. doi: 10.1080/14786419.2020.1821016. Epub 2020 Sep 18.

Authors

Tjitjik Srie Tjahjandarie¹, Mulyadi Tanjung¹, Ratih Dewi Saputri¹, Devina Oktari Rahayu¹, Alfiah Nur Irza Gunawan¹, Muhammad Fajar Aldin¹

Affiliation

¹ Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.

PMID: 32945195
DOI: 10.1080/14786419.2020.1821016

Abstract

Two new 2-arylbenzofurans, sesbagrandiflorain D (1) and E (2) along with two known 2-arylbenzofurans, spinosan A (3) and spinosan B (4) were isolated from the stem bark of Sesbania grandiflora L. The structure of two new compounds established by HRESIMS, 1 D NMR (¹H, ¹³C) and 2 D NMR (HMQC, HMBC) spectra. Compounds (1-4) assayed for their cytotoxicity towards three human cancer cells (MCF-7, HeLa, and WiDr). Compound 1 showed very high activity against MCF-7 and WiDr with an IC₅₀ value of 0.06 and 0.60 μg/mL, respectively.

Keywords: 2-arylbenzofuran; Sesbania grandiflora L; cancer cell; sesbagrandiflorain D and E.

MeSH terms

Humans
Neoplasms*
Plant Extracts / pharmacology
Sesbania*

Substances

Plant Extracts