Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 (HSP70) to block its function. Importantly, HSP70 promotes MLKL polymerization to activate necroptosis.
Keywords: HSP70; MLKL; Necroptosis; ✚-➔regulated cell death.
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.