Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress

Abstract

We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells. In addition to increased methylation of chromatin proteins that favors senescence-associated secretory phenotype (SASP) activation, our study unraveled global hypo-methylation of RNA-binding proteins, which - we speculate - may promote their phase separation and stress granules formation.

Keywords: Arginine methylation; LLPS; PRMT1; SASP; cisplatin; mass spectrometry-based proteomics; phosphorylation; stress granules.