Abstract
F420H2-oxidase (FprA) catalyses the four-electron reduction of O2 to 2H2O using the reduced form of F420 as electron donor. The hydrophobic O2-channel detected by Kr-derivatization and the concerted movement of a gating loop could contribute to prevent unwanted side-reaction between the catalytic intermediates and solvents, therefore preventing reactive oxygen species formation.
MeSH terms
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Electrons*
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Hydrogen Peroxide / chemistry
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Hydrogen Peroxide / metabolism
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Hydrophobic and Hydrophilic Interactions
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Krypton / chemistry
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Krypton / metabolism*
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Methanobacteriaceae / enzymology
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Models, Molecular
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Oxidation-Reduction
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Oxidoreductases / chemistry
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Oxidoreductases / metabolism*
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Oxygen / chemistry
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Oxygen / metabolism*
Substances
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Krypton
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Hydrogen Peroxide
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Oxidoreductases
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Oxygen