Application of The Dess-Martin Oxidation in Total Synthesis of Natural Products

Majid M Heravi; Tayebe Momeni; Vahideh Zadsirjan; Leila Mohammadi

doi:10.2174/1570179417666200917102634

Application of The Dess-Martin Oxidation in Total Synthesis of Natural Products

Curr Org Synth. 2021;18(2):125-196. doi: 10.2174/1570179417666200917102634.

Authors

Majid M Heravi¹, Tayebe Momeni¹, Vahideh Zadsirjan¹, Leila Mohammadi¹

Affiliation

¹ Department of Chemistry, School of Science, Alzahra University, POBox 1993891176, Vanak, Tehran, Iran.

PMID: 32940184
DOI: 10.2174/1570179417666200917102634

Abstract

Dess-Martin periodinane (DMP), a commercially available chemical, is frequently utilized as a mild oxidative agent for the selective oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones, respectively. DMP shows several merits over other common oxidative agents such as chromiumand DMSO-based oxidants; thus, it is habitually employed in the total synthesis of natural products. In this review, we try to underscore the applications of DMP as an effective oxidant in an appropriate step (steps) in the multi-step total synthesis of natural products.

Keywords: DMP; Dess-Martin periodinane; alcohols; aldehydes; ketones; natural products; oxidation; total synthesis.